The main dishes to remember:
- A high genetic risk and lifestyle for the CAD was linked to an increased risk of dementia.
- The intervention of the lifestyle can improve the risk of dementia, regardless of the genetic risk of CAD.
A lifestyle in heart health can reduce the risk of dementia, even for people with high genetic risk of coronary disease, according to new data published in Traffic.
“”CAD and dementia There are two of the main causes of death and disability worldwide, representing an annual burden estimated at 9 million and 2 million deaths respectively. The two conditions occur as a result of distinct and complex pathological processes resulting from various pathogens, but the accumulation of evidence suggests that each can share common risk factors, and sometimes potentially modifiable, which act simultaneously to increase the risk of the two diseases, ” Arisa SittichokkanonFrom the Princess Srisavangavadhana College of Medicine of the Chulabhorn Royal Academy in Bangkok, and colleagues wrote. “No study to date has studied the potential of shared underlying genetic paths to simultaneously contribute to the pathogenesis of the two diseases or has studied the impact that Healthy lifestyle behavior earlier in life can have on different dementia results. “”
This study included data from 365,782 British biobank participants who were exempt from dementia for at least 5 years after the initial assessment.
The genetic risk of CAD has been evaluated using polygenic risk scores at the genome level and potential attenuation of risk of dementia based on lifestyle has been evaluated using the essential lifestyle risk score of the life of the modified American Heart.
The risk of the essential lifestyle risk of life AHA is used to measure the impact of lifestyle on cardiac health using eight biological and behavioral variables: BMI, lipids, blood sugar, PA, diet, physical activity, smoking status and sleep duration.
The main results were dementia all causes, Alzheimer’s disease and vascular dementia.
During a median of almost 14 years of follow -up, 8,870 dementia incidents were reported.
Researchers observed that high genetic risk scores and risk-style risk scores for the CAD were respectively associated with a high risk of dementia all causes of causes (HR per standard deviation (SD) of the genetic risk score = 1.1; 95%CI, 1.08-1.12; P <0.001; HR by SD increase in risk of lifestyle risk = 1.04; 95%CI, 1.02-1.06; P = .006).
A high genetic and lifestyle risk for CAD was mainly attributed to the risk of vascular dementia (HR for genetic risk score = 1.16; 95%CI, 1.11-1.21; P <0.001; HR for the lifestyle risk score = 1.15; 1.09-1.22; P <0.001), while Alzheimer's disease had a moderate association with genetic risk for the only dad (HR = 1.09; 95%CI, 1.06-1,13; P <0.001), according to the study.
The researchers said that the risk of lifestyle risk score had an additive impact, rather than on an interactive effect, on genetic risk scores, with participants in the highest tertiles for genetic risk and lifestyle for the CAD having a significantly high risk of developing vascular dementia compared to those in the lowest tertiles of each (hr = 1.71; 95% 1,39-2.11; P <0.001).
The risk of vascular dementia was attenuated from 40% to 50% in participants with low lifestyle risk scores for the CAD at the start, regardless of the underlying genetic risk for the CAD (P For all <0.001), according to the study.
“Our results suggest that an underlying genetic risk of coronary disease is associated both with an increased risk of cerebroscle damage in quarantine with late life and an increased risk of vascular dementia in long-term monitoring,” the researchers wrote. “Healthy lifestyle behavior during the median period at the end of life can alleviate this risk, regardless of genetic predisposition, especially in people who can be at risk of developing dementia caused by an underlying vascular pathology.”