The healthy lifestyle and food choices are associated with a reduction in the risk of death all causes in patients with non -metastatic prostate cancer, but these choices are not associated with specific survival for prostate cancer, according to research published in Jama Network Open.
The researchers evaluated the links between the lifestyle and the scores of the food index and the risk of death in a prospective and multiethnic cohort of men diagnosed with non -metastatic prostate cancer. To assess the lifestyle, the researchers used the 2021 prostate cancer behavior score, which incorporates the body mass index, total physical activity and smoking status. The researchers also carried out analyzes incorporating this score as well as food factors, including the supply of saturated fats, whole milk, alcohol and transformed meat.
The analysis included 2603 patients. In diagnosis, 89.3%had localized prostate cancer and 76.1%had Gleason quality of at least 7. Treatments included surgery (32.8%), radiotherapy (46.4%) and hormone therapy (30.2%).
The patients were followed for a median of 14.5 years of diagnosis and a median of 10.9 years from the return of the questionnaires. There was a total of 1346 deaths during the follow -up. Current death causes included prostate cancer (14.6%), cardiovascular disease (26.4%), other cancers (20.9%), cerebrovascular diseases (5.2%) and chronic pulmonary disease (3.4%).
In a fully adjusted model, each increase in 1 point of the 2021 prostate cancer behavior score has been significantly associated with a reduction in mortality all causes (risk ratio (HR) per point, 0.69; 95%CI, 0.63-0.77; P <0.001). The results were similar when the food factors were also taken into account (HR per point, 0.70; 95%CI, 0.64-0.77; P <0.001).
2021 higher prostate cancer behavior scores were also associated with a lower risk of morality linked to cardiovascular (HR per point, 0.67; 95% CI 0.56-0.79; P <0.001), and the results were similar when food factors were also included (HR per point, 0.68; 95%CI, 0.58-0.79; P <0.001).
However, the higher prostate cancer behavior scores in 2021 were not associated with a reduction in the risk of specific mortality in prostate cancer when they were considered alone (HR per point, 0.90; 95% CI 0.69-1.18; P = 0.45) or in conjunction with food factors (HR per point, 0.96; 95% CI 0.75-1.21; P = 0.71).
Buer 2021 higher prostate cancer behavior scores were significantly associated with a lower risk of prostate cancer in black patients (HR per point, 0.46, 95% CI 0.24-0.88) but not among other racial and ethnic groups. And the results were no longer significant for black patients when the food factors were also included (HR per point, 0.70; 95%CI, 0.42-1.16).
“The results suggest improvements in overall and cardiovascular mortality, although the effect on specific mortality in prostate cancer does not reach statistical meaning in all ethnic groups – largely due to limited statistical power,” said J. Ryan Mark, MDFrom Fox Chase Cancer Center to Philadelphia, which was not involved in this study.
“In particular, the absence of recurrence and progression data presents a challenge in the application of study instruments to fully assess the influence of food and lifestyle on the results of prostate cancer,” he added. “Nevertheless, the trends identified in this research provide valuable information for the conception of future studies which explore the role of healthy life in various populations. More immediately, they provide additional evidence to support the advice we offer to patients at a time when they can be the most receptive to the adoption of healthier habits. “
Disclosure: This research was supported by various subsidies. Some study authors have revealed conflicts of interest, which may be found in the initial reference. Dr. Mark revealed a relationship with intuitive surgery.
This article originally appeared on Cancer therapy advisor