Life -style and metformin interventions have long -term advantages in the reduction of type 2 diabetes

The American diabetes prevention program, or DPP, reported on April 28, the 21 -year -old monitoring of a randomized clinical trial, showing that the intervention of an original intensive lifestyle has reduced the development of diabetes by 24% and metformin has reduced the development of diabetes by 17%.

The DPP had previously shown that after the first three years of study lifestyle aimed at moderate weight loss and increase physical activityand medication metformin has reduced the start of type 2 diabetes 58% and 31%, respectively, compared to a placebo medicine. All participants were adults at high risk of developing diabetes.

Long -term follow -up of 3,195 DPP participants, reported In Lancet Diabetes and endocrinologyhighlights the long -term advantages of interventions to prevent the development of diabetes. Compared to the original placebo group, the median time without diabetes has been extended by 3.5 years in the lifestyle group and 2.5 years in the metformin group.

The original DPP clinical trial began in 1996, when participants were 51 years old, on average and 45% identified as members of American minority groups who are particularly affected by type 2. Diabetes of type 2.. The long-term advantages of the two interventions have extended into all racial-ethnic groups included in the study.

In summary, the big intervention The effects observed during the first years of the trial led to a sustained reduction in the development of diabetes over 21 years, increasing the years without diabetes. Despite the challenges in maintaining long -term intensity lifestyle And medicine interventions, even short -term interventions have lasting advantages, according to the study.

The DPP / DPPOS site of the Pennington Biomedical Research Center currently follows 76 residents of the Baton Rouge region which have been in the study for almost 30 years.

“Since the founding executive director of Pennington Biomedical, Dr George Bray, began to study these people in 1996, the participants in the DPP posted some of the best qualities that Louisians have to offer: hard work, dedication and commitment to a greater good that is much more important than themselves,” said the head of the current site Dr. Owen Carmichael, Biomedical and professor at Pennington Biomed.

“Frankly, these Louisiana has helped to change the course of modern medicine – not just at Baton Rouge, but around the world – for the best.”